Endoplasmic reticulum how does it work

Chang, J. Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Raiborg, C. Repeated ER—endosome contacts promote endosome translocation and neurite outgrowth.

Nature , — This promotes trafficking of late endosomes to the cell exterior. Pankiv, S. Matsuzaki, F. Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation. Cell 22 , — Vance, J. Brefeldin A does not inhibit the movement of phosphatidylethanolamine from its sites for synthesis to the cell surface. Wirtz, K. Exchange of phospholipids between liver mitochondria and microsomes in vitro.

Lev, S. Non-vesicular lipid transport by lipid-transfer proteins and beyond. Im, Y. Structural mechanism for sterol sensing and transport by OSBP-related proteins. Kopec, K. Dennis, E. Intracellular sites of lipid synthesis and the biogenesis of mitochondria.

Lipid Res. Osman, C. Making heads or tails of phospholipids in mitochondria. Toulmay, A. A conserved membrane-binding domain targets proteins to organelle contact sites.

Schauder, C. Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria.

Tamura, Y. Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. Tan, T. Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. Nguyen, T. Traffic 13 , — Voss, C. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. Elbaz-Alon, Y. A dynamic interface between vacuoles and mitochondria in yeast. Cell 30 , 95— Cellular metabolism regulates contact sites between vacuoles and mitochondria.

Cell 30 , 86—94 Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway. Traffic 4 , — Neufeld, E. Intracellular trafficking of cholesterol monitored with a cyclodextrin. Liscum, L. The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts. Infante, R. NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes.

Kwon, H. Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.

Du, X. A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. Demonstrated that depletion of tail-anchored ER protein ORP5 resulted in cholesterol accumulation in the external membranes of late endosomes, leading to the model in which ORP5 accepts cholesterol from late endosome NPC1 and transfers it to the ER.

Van der Kant, R. Peretti, D. Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport. Cell 19 , — Hanada, K. Molecular machinery for non-vesicular trafficking of ceramide. D'Angelo, G. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.

Nature , 62—67 Litvak, V. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Mesmin, B. Perry, R. Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein.

Cell 17 , — Loewen, C. The VAP protein family: from cellular functions to motor neuron disease. Trends Cell Biol. Amarilio, R. Differential regulation of endoplasmic reticulum structure through VAP—Nir protein interaction.

Foskett, J. Tovey, S. Taylor, C. IP3 receptors: toward understanding their activation. Cold Spring Harb. Shuai, J. Cell Calcium 37 , — Rizzuto, R. Morgan, A. De Stefani, D. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Baughman, J. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Mitochondria as sensors and regulators of calcium signalling. Scorrano, L. Zong, W. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. Imaging interorganelle contacts and local calcium dynamics at the ER—mitochondrial interface. Cell 39 , — De Brito, O. Mitofusin 2 tethers endoplasmic reticulum to mitochondria.

Filadi, R. Mitofusin 2 ablation increases endoplasmic reticulum—mitochondria coupling. USA , E—E Szabadkai, G. Giorgi, C. The double membranes of smooth and rough ER form sacs called cisternae. When enough proteins have been synthesized, they collect and are pinched off in vesicles. The vesicles often move to the Golgi apparatus for additional protein packaging and distribution. It is important in the creation and storage of lipids and steroids. Steroids are a type of ringed organic molecule used for many purposes in an organism.

They are not always about building the muscle mass of a weight lifter. Cells in your body that release oils also have more SER than most cells. It is able to store many ions in solution that the cell will need at a later time.

It is easier to have them stored in a pack for easy use. Smooth endoplasmic reticulum lacks ribosomes and helps synthesize and concentrate various substances needed by the cell.

The endoplasmic reticulum can either be smooth or rough, and in general its function is to produce proteins for the rest of the cell to function. The rough endoplasmic reticulum has on it ribosomes, which are small, round organelles whose function it is to make those proteins. Sometimes, when those proteins are made improperly, the proteins stay within the endoplasmic reticulum. They're retained and the endoplasmic reticulum becomes engorged because it seems to be constipated, in a way, and the proteins don't get out where they're suppose to go.